Sirolimus

Sirolimus (INN / USAN), oo sidoo kale loo yaqaan 'rapamycin', waa daawo difaac ka hortag ah oo loo isticmaalo in looga hortago diidmada xubinta taranka; waxay si gaar ah waxtar ugu leedahay tallaalida kelyaha. Macrolide, sirolimus waxaa markii uguhoreysay laga helay wax soo saarka bakteeriyada Streptomyces hygroscopicus ee muunad carro ah oo laga soo qaaday Island Island - jasiirad sidoo kale loo yaqaan "Rapa Nui", sidaas darteed magaca. Waxaa lagu suuq geeyay magaca ganacsiga Rapamune ee Wyeth.
Sirolimus waxaa asal ahaan loo horumariyey inuu yahay wakiilka antifungal. Si kastaba ha noqotee, tani waa laga tagay markii la ogaaday inay leedahay awood difaac oo xakameyn iyo xakameyn.
Saamaynta ka-hortagga faafinta ee sirolimus ayaa laga yaabaa inay door ku leedahay daaweynta kansarka. Dhawaan, waxaa la muujiyay in sirolimus uu hor istaagay horumarka maqaarka dermal Kaposi ee bukaanka qaba kelyaha lagu tallaalay. Kuwa kale ee ka hortaga mTOR sida temsirolimus (CCI-779) ama everolimus (RAD001) ayaa la baarayaa si loogu isticmaalo kansarka sida glioblastoma multiforme iyo mantle cell lymphoma.
Daaweynta isku dhafka ah ee doxorubicin iyo sirolimus ayaa la muujiyey inay waddo unugyada 'AKT-lymphomas-ka' oo lagu daweeyo jiirka. Calaamadda 'Akt signaling' waxay dhiirrigelisaa badbaadada unugyada ee 'lymphomas-ka' Akt-positive iyo ficillada looga hortago saameynta cytotoxic ee daweynta kemotherabi sida doxorubicin ama cyclophosphamide Sirolimus ayaa xannibaya astaamaha Akt unugyada ayaa lumiya iska caabbintooda daaweynta kiimikada. Bcl-2-lymphomas-ka togan ayaa gabi ahaanba u adkeysanayay daaweynta; sidoo kale eIF4E muujinta lymphomas oo xasaasi u ah sirolimus. Rapamycin ma muujin wax saameyn ah kaligeed.