Linaclotide

Ku iibso Linaclotide qiimo jaban. Tayo Sare. Qiimaha hooseeya. Waydiiso Hadda!
U hel Linaclotide Iib; Ka hel Qiimaha Linaclotide Soo saaraha/Alaab-qeybiyaha;Qaybta,Shaqada - Bolise.

[Isku xigxiga] H-Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr-OH cyclic (1-6), (2-10), (5- 13) -Tris (disulfide)
[Cas MAYA. ] 851199-59-2
[Formula Molecular] C59H79N15O21S6
[Miisaanka Molecular] 1526.73
[Muuqaalka] Budada Cad
[Nadaafad] 98%

[Codsi]
Daraasadda mindhicirka xanaaqa ee calool-istaagga (IBS-C) iyo calool-istaagga joogtada ah.

Ku saabsan Linaclotide
Linaclotide waa guanylate cyclase-C reseptor agonist (GCCA) oo leh labadaba xanuunka visceral iyo dhaqdhaqaaqa endocrine. Linaclotide iyo dheef-shiid kiimikaadka firfircoon labadaba waxay ku xidhi karaan guanylate cyclase-C (GC-C) reseptors ee dusha iftiinka ee epithelium yar ee mindhicirka. Noocyada xayawaanka, iyada oo loo marayo kicinta GC-C, linaclotide waxay yareyn kartaa xanuunka visceral waxayna hagaajin kartaa xawaaraha socodka caloosha iyo mindhicirka. Bini'aadamka, daawadu waxay sidoo kale kordhin kartaa xawaaraha socodka mindhicirka. Natiijada firfircoonida GC-C waxay kordhisay uruurinta unugyada gudaha iyo ka-baxsan cGMP (cyclic guanosine monophosphate). cGMP ka baxsan unugyada waxay yareyn kartaa dhaqdhaqaaqa fiilooyinka dareemayaasha xanuunka waxayna yareyn kartaa xanuunka visceral ee xayawaanka moodada ah. Intracellular cGMP waxay kordhin kartaa dheecaanka chloride iyo bicarbonate ee lumen ee mindhicirka yar iyada oo la hawlgelinayo CFTR (cystic fibrosis transmembrane conductance conductance), taas oo ugu dambeyntii keenta dheecaanka dheecaanka xiidmaha yar iyo socodka xiidmaha degdega ah.