PNC-27

Ku iibso PNC-27 Peptide qiimo Jumlo ah. Tayo Sare. Qiimo jaban Waydiiso Hadda!
Anti-kansarka Peptide PNC-27 Qiimaha & Qiimaha; Ka hel PNC-27 Iibka Soo saaraha/Alaab-qeybiyaha, Faa'iidooyinka - Bolise.

[Foomka Molecular] C188H293N53O44S
[Miisaanka Molecular] 4031.7
[Muuqaalka] Budada Cad
[Nadaafad] 99%
[Isha] synthetic

[Waxqabadka]
1. Dhaqdhaqaaqa ka hortagga kansarka;
2. xakamaynta burooyinka;
3. cytotoxicity unugyada kansarka;

Ku saabsan PNC-27
PNC-27, peptide anticancer, oo ka kooban HDM-2 xidhitaanka domain u dhigma p53 hadhaaga 12-26 iyo a transmembrane domain interating domain, ayaa la ogaaday in uu dilo unugyada kansarka laakiin aan ahayn unugyo caadi ah by kicinta lysis xuubka. Qaab dhismeedka 3D ee haraaga p53 ee PNC-27 ayaa si toos ah u dulmaro qaab dhismeedka haraaga isku midka ah ee isku xira HDM-2, isagoo soo jeedinaya in peptide-kan laga yaabo inuu bartilmaameedsado HDM-2 ee xuubka unugyada. Cilmi-baadhayaashu waxay heleen heerar muhiim ah oo HDM-2 ah oo ku jira xuubabka unugyada unugyada kansarka ee kala duwan laakiin maaha qaar ka mid ah khadadka unugyada aan isbeddelin. Tijaabooyin kala-saarid, PNC-27 peptide oo ku xidhan xuubka unugyada HDM-2. Cilmi-baadhayaashu waxay adeegsadeen calaamadda xuub-xajinta si ay ugu gudbiyaan plasmid-ka muujinaya dhererka buuxa ee HDM-2 ee PNC-27-aan isbeddelin unugyada MCF-10-2A waxayna ogaadeen in unugyadani ay muujiyeen dherer buuxa HDM-2 oo ku yaal dusha unuga. unugyo lid ku ah PNC-27. Waxaan soo gabagabeynay in PNC-27 ay bartilmaameedsato HDM-2 ee xuubka unugyada kansarka, taasoo u oggolaaneysa inay si door ah u keento lysis xuubka unugyadan.
PNC-27 peptide waa unug borotiin ah oo aan sun ahayn. Kiliinik ahaan, PNC-27 waxay ku dhejin kartaa unugyada kansarka oo waxay heli karaan reseptors gaar ah, taasoo keenta unugyada kansarku inay dhintaan.