Catestatin

[Muuqaal] Budada-cad-cad
[Waxqabadka]
1. Hagaajinta tayada hurdada
2. In kor loo qaado difaaca jirka
3. Kor u qaad nuugista calcium
Ku saabsan Catestatin
Catestatin waa haraaga amino acid 21, cationic, peptide hydrophobic. Catestatin waa polypeptide firfircoon oo dhowaan la helay, oo laga soo qaatay chromogranin A, taas oo joojin karta sii deynta catecholamines, joojiso dhiig-karka muhiimka ah iyo wadnaha oo aan shaqeynin, oo ka soo horjeeda hypoxia myocardial hypoxia ama ischemia / reperfusion dhaawaca.
Catestatin waa nicotinic antagonist aan tartan lahayn oo joojisa sii deynta catecholamine iyada oo loo marayo nAChRs.
Catestatin waa peptide-ka ilaalinta wadnaha iyo xididdada cusub oo ay soo saartay kala-baxa chromoprotein A, waxaa lagu muujiyaa unugyada chromaffin adrenal, neurons adrenergic iyo myocardium, wuxuuna sameeyaa saameyno dhowr ah oo ilaalinta wadnaha iyo xididdada iyada oo loo marayo autocrine / paracrine.
Catestatin waxay si xun u xakameyn kartaa sii deynta catecholamines, waxay kor u qaadaa hoos u dhigista unugyada mastarada, waxay xakameysaa shaqada habdhiska dareenka, ka dibna waxay dejisaa xididdada dhiigga waxayna ka soo horjeedaa dhacdooyinka hypertension.Waxay kor u qaadaa angiogenesis iyada oo kor u qaadeysa sii deynta aasaasiga ah ee koritaanka fibroblast ee unugyada endothelial. iyo dhaqaajinta dariiqa calaamadaynta MAPK.
Catestatin waxay hagaajin kartaa difaaca jirka, maaddooyinka ku jira kateetatin waxay kicin karaan badinta lymphocytes, waxay gacan ka geystaan ​​hagaajinta difaaca jirka, waxayna ka hortagaan in jirka lagu weeraro fayrasyada. Ka dib markii Catestatin uu go'o, morphine u eg peptide firfircoon ayaa la soo saari doonaa. Peptide-ka firfircooni wuxuu kaa caawin karaa nafisinta iyo dhimista walbahaarka, wuxuu dejin karaa oo caawin karaa hurdada, wuxuuna hagaajin karaa tayada hurdada. Intaa waxaa dheer, Catestatin waxay sidoo kale kor u qaadi kartaa nuugista calcium.